Leu骨髓白血病细胞分化过程中的RNA编

TitleRNAeditingsignatureduringmyeloidleukemiacelldifferentiationAbstractAdenosinedeaminasesactingonRNA(ADARs)arekeyproteinsforhematopoieticstemcellself-renewalandforsurvivalofdifferentiatingprogenitorcells.However,theirspecificroleinmyeloidcellmaturationhasbeenpoorlyinvestigated.HereweshowthatADAR1ispresentatbasallevelintheprimarymyeloidleukemiacellsobtainedfrompatientsatdiagnosisaswellasinmyeloidU-andTHP1celllinesanditsexpressioncorrelateswiththeeditinglevels.Uponphorbol-myristateacetateorVitaminD3/granulocytemacrophagecolony-stimulatingfactor(GM-CSF)-drivendifferentiation,bothADAR1andADAR2enzymesareupregulated,withacon







































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