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CytoskeletonDynamicsAreNecessaryforEarlyEventsofLateralRootInitiationinArabidopsisFirstauthor:AmayaVilchesBarro;Affiliations:UniversityofHeidelberg(海德堡大学):Heidelberg,Germany
Correspondingauthor:AlexisMaizel
Howplantcellsre-establishdifferentialgrowthtoinitiateorgansispoorlyunderstood.Morphogenesisoflateralrootsreliesontheasymmetriccelldivisionofinitiallysymmetricfoundercells.Thisdivisionisprecededbythetightlycontrolledasymmetricradialexpansionofthesecells.Thecellularmechanismsthatlicenseandensurethecoordinationoftheseeventsareunknown.Here,wequantitativelyanalyzemicrotubuleandF-actindynamicsduringlateralrootinitiation.Usingmutantsandpharmacologicalandtissue-specificgeneticperturbations,weshowthatdynamicreorganizationofbothmicrotubuleandF-actinnetworksisnecessaryfortheasymmetricexpansionofthefoundercells.Thiscytoskeletonremodelingintertwineswithauxinsignalinginthepericycleandendodermisinorderforfoundercellstoacquireabasicpolarityrequiredforinitiatinglateralrootdevelopment.OurresultsrevealtheconservationofcellremodelingandpolarizationstrategiesbetweentheArabidopsiszygoteandlateralrootfoundercells.Weproposethatcoordinated,auxin-drivenreorganizationofthecytoskeletonlicensesasymmetriccellgrowthanddivisionsduringembryonicandpost-embryonicorganogenesis.
有关植物细胞如何重新建立分化生长以起始新器官的形成这方面的研究还不够透彻。侧根的形态建成依赖于起始的、对称性建成细胞（foundercell）的不对称细胞分裂。在该分裂之前，这些细胞受到了严格的径向不对称扩张调控。然而，该现象潜在的分子调控机制还不清楚。本文中，作者定量分析了侧根起始过程中微管和F-肌动蛋白动态变化。利用突变体、药理学及组织特异性基因扰动，作者发现微管和F-肌动蛋白的动态重组对于建成细胞的不对称分裂是必须的。该细胞骨架重塑与根中柱鞘和内皮层组织中的生长素信号紧密相关，使得建成细胞能够获得一个基本的极性，从而能够起始侧根的发育。本文的结果揭示了拟南芥合子与侧根建成细胞之间细胞重塑和极性策略的保守性。作者认为协同的、由生长素驱动的细胞骨架重组使得胚胎发育和胚后器官形成过程中细胞的不对称生长和分裂成为可能。
通讯：AlexisMaizel(
